?? ??? ????? ?????? ?? ??? ???? ????? ?????? ???????? ?????? ????? ??????? ??? ??????? ??? ??? ??????? ?? ???? ???? ?????? ??????? ?????? ??? ???? ?????? ??????? ?????? ?????? ??????? ??? ?? ??? ?????? ??????.[?]???? ????????? ??????? ??? ?????? ????? ??????????:[??] ????? ????? ?????????? ?? ????? ???????.In check out of dose-dependent adverse rea